Germ Theory
Louis Pasteur demonstrated that invisible organisms caused fermentation and disease, and Joseph Lister applied the insight to surgery with antiseptics — replacing centuries of belief that illness came from bad air, imbalanced humors, or divine judgment. Doctors began washing their hands. Within decades, sanitation, vaccination, and clean water added more years to human life than any medical treatment before or since. Earlier plagues had been fought blind; from here, people knew what they were fighting.
A new way to record or transmit information lowers the cost of copying ideas and reorders who holds knowledge and power.