The Cocoliztli Epidemics
After smallpox came something worse. Two epidemics the Aztecs called cocoliztli — pestilence — killed perhaps 80% of the survivors of the conquest, with victims bleeding from the nose and eyes and dying within days. Spanish physicians had never seen it and neither had the Nahua. DNA recovered from teeth in a mass grave in 2018 pointed to a strain of salmonella, possibly introduced from Europe and possibly amplified by drought and the forced resettlement and labour the survivors were living under. Mexico's population fell from roughly 20 million to under 2 million within a century of contact.
A pathogen spreads through a population and reshapes its demography, economy, and beliefs at once.