John Snow and the Broad Street Pump
Cholera killed by the hundreds of thousands as it spread out of India along the new steamship and railway routes, and everyone knew it travelled in bad air. A London physician, John Snow, doubted it, and when an outbreak killed 600 people in a few streets of Soho he mapped every death, found they clustered around one water pump, and had the handle removed. He could not prove why — germ theory did not exist yet — but the map did the arguing. The pump was fed by a well dug three feet from a leaking cesspit.
A pathogen spreads through a population and reshapes its demography, economy, and beliefs at once.